![]() Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review. The treatment of certain cervical-spine disorders by anterior removal of the intervertebral disc and interbody fusion. The anterior approach for removal of ruptured cervical disks. Cervical spondylotic myelopathy: national trends in the treatment and peri-operative outcomes over 10 years. Passias PG, Marascalchi BJ, Boniello AJ, et al. The novel i-FACTOR is not only cost-effective compared to autograft in ACDF surgery but is the dominant economic strategy.Īnterior cervical discectomy and fusion cervical spondylosis cost analysis cost-effectiveness decision analysis i-factor spine allograft spine fusion. In a threshold sensitivity analysis, the cost of i-FACTOR could theoretically be increased 70-fold and still remain cost-effective. The ICER at 90 days was $13,333 per QALY and became negative ("dominated") relative to the control group within one year and onwards. The savings proved to be incremental over time, increasing to 3.7% over an extrapolated 10 years. In all scenarios, i-FACTOR reduced costs within the first year by 1.4% to 2.1%. Cost-effectiveness was expressed as an incremental cost-effectiveness ratio (ICER). Health-related utility outcome was expressed in quality-adjusted life years (QALYs). In the base-case analysis, both health and societal system costs were evaluated. Two primary outcome measures were assessed: cost and utility. We analyzed various real-world scenarios, including inpatient and outpatient surgical settings as well as private versus public insurances. Patients randomly received either autograft (N = 154) or i-Factor (N = 165). The patient cohort was extracted from a prospective, multicenter randomized control trial (RCT) from twenty-two North American centers. ![]() To evaluate the cost-effectiveness of i-FACTOR compared to autograft for patients undergoing ACDF surgery. Cost-effectiveness of these innovations remains an often-overlooked aspect of this effort. The efficacy and safety of traditional anterior cervical discectomy and fusion (ACDF) surgery has improved with the introduction of new implants and compounds. ![]() We conducted decision analytical modeling using a Markov model to determine the ICER of i-factor compared to autograft in ACDF surgery. ![]()
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